Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.76 |
| ▸ | HPGD | P15428 | 6/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.75 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | BRD4 | O60885 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.65 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.65 |
| ▸ | EDNRA | P25101 | 1/20 | 0.65 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.65 |
| ▸ | TOP2A | P11388 | 5/20 | 0.52 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
| ▸ | TOP1 | P11387 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL10765060 | 0.99 | KDM4E (0.75) | KDM4EHSD17B10HPGDALDH1A1PMP22 | |
| Hydrochloric Acid SCHEMBL10743594 | 0.99 | KDM4E (0.77) | KDM4EHSD17B10HPGDALDH1A1PMP22 | |
| SCHEMBL11022192 | 0.96 | KDM4E (0.71) | KDM4EHSD17B10HPGDALDH1A1PMP22 | |
| SCHEMBL10769533 | 0.92 | KDM4E (0.65) | KDM4EHSD17B10HPGDALDH1A1PMP22 | |
| SCHEMBL10459451 | 0.92 | KDM4E (0.65) | KDM4EHSD17B10HPGDALDH1A1PMP22 | |
| Hydrochloric Acid SCHEMBL11187466 | 0.91 | KDM4E (0.68) | KDM4EHSD17B10HPGDALDH1A1PMP22 | |
| SCHEMBL10765880 | 0.91 | KDM4E (0.64) | KDM4EHSD17B10HPGDALDH1A1PMP22 | |
| SCHEMBL6305606 | 0.90 | KDM4E (0.80) | KDM4EHSD17B10HPGDALDH1A1PMP22 | |
| SCHEMBL11185030 | 0.90 | KDM4E (0.71) | KDM4EHSD17B10HPGDALDH1A1PMP22 | |
| Hydrochloric Acid SCHEMBL10764169 | 0.90 | KDM4E (0.65) | KDM4EHSD17B10HPGDALDH1A1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57145862-A | — | — | None | — | — | JP | disclosed |
| JP-61085381-A | — | — | None | — | — | JP | disclosed |
| US-8093381-B2 | Method of synthesis of fluoroquinolones | BIOCODEX (FR) | 2012-01-10 | — | — | US | disclosed |
| EP-2138490-B1 | New method for synthesis of fluoroquinolones | BIOCODEX (FR) | 2011-08-31 | — | — | EP | disclosed |
| US-20090054643-A1 | NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES | BIOCODEX (FR) | 2009-02-26 | — | — | US | disclosed |
| US-6492373-B2 | FOR TREATMENT OF BACTERIAL INFECTIONS AND/OR RENAL CANCER DISEASES | PHARMACEUTICAL INDUSTRY TECHNOLOGY AND DEVELOPMENT CENTER (TW) | 2002-12-10 | — | — | US | disclosed |
| US-20020061895-A1 | 6-fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and pharmaceutical compositions | PHARMACEUTICAL INDUSTRY TECHNOLOGY | 2002-05-23 | — | — | US | disclosed |
| US-5753658-A | FOR TREATMENT OF BACTERIAL INFECTIONS | SENJU PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5672600-A | Antimicrobial dithiocarbamoyl quinolones | THE PROCTER & GAMBLE COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| US-5387748-A | Antimicrobial dithiocarbamoyl quinolones | PROCTER & GAMBLE PHARMACEUTICALS, INC. (US) | 1995-02-07 | — | — | US | disclosed |
| EP-0329719-A1 | PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACID DERIVATIVES | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1989-08-30 | — | — | EP | disclosed |
| WO-1988010253-A1 | PROCESS FOR THE PREPARATION OF QUINOLINE CARBOXYLIC ACID DERIVATIVES | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. (HU) | 1988-12-29 | — | — | WO | disclosed |
| EP-0235762-A1 | 8-Position substituted quinolone-carboxylic acid derivatives and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1987-09-09 | — | — | EP | disclosed |
| JP-S6185381-A | PREPARATION OF 1-ETHYL-6, 8-DIFLUORO-1, 4-DIHYDRO-4-OXO-7-PIPERAZINYLQUINOLINE-3-CARBOXYLIC ACID DERIVATIVE | HOKURIKU SEIYAKU CO LTD | 1986-04-30 | — | — | JP | disclosed |
| US-4530930-A | Antimicrobial 1-ethyl-6,8-difluoro-1,4-dihydro-7-(1-imidazolyl)-4-oxoquinoline-3-carboxylic acid derivatives | KANEBO, LTD. (JP) | 1985-07-23 | — | — | US | disclosed |
| EP-0115049-A1 | 1-Ethyl-6,8-difluoro-1,4-dihydro-7-(1-imidazolyl)-4-oxoquinoline-3-carboxylic acid derivatives, process for preparing the same and anti-microbial compositions | KANEBO, LTD. (JP) | 1984-08-08 | — | — | EP | disclosed |
| US-4429127-A | BACTERICIDES | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1984-01-31 | — | — | US | disclosed |
| US-4398029-A | BACTERICIDES | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1983-08-09 | — | — | US | disclosed |
| JP-S57145862-A | QUINOLINECARBOXYLIC ACID DERIVATIVE | KYORIN PHARMACEUT CO LTD | 1982-09-09 | — | — | JP | disclosed |
| JP-S06185381-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054643-A1 | NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES | NQO2, Q6ZSR9, QARS1 | KDM4E 2435/4885HSD17B10 1768/4885HPGD 1739/4885 |
| US-20020061895-A1 | 6-fluoro-1,4-dihydro-7-[4-(2-hydroxyiminoethyl)-1-piperazinyl]-4-oxoquinoline-3-carboxylic acid derivatives, their preparation and pharmaceutical compositions | ATP6V1B1, GLS, RCC2 | KDM4E 1113/4885HSD17B10 1679/4885HPGD 1193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.