Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.51 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29896397 | 1.00 | LMNA (0.59) | LMNAHPGDMAOBMAOAMEN1 | |
| SCHEMBL5552735 | 0.89 | MRGPRX4 (0.59) | LMNAHPGDMAOBMAOAMEN1 | |
| SCHEMBL391547 | 0.87 | MEN1 (0.71) | LMNAHPGDMAOBMEN1KMT2A | |
| SCHEMBL183994 | 0.87 | LMNA (0.70) | LMNAHPGDMAOBMEN1KMT2A | |
| SCHEMBL2806822 | 0.87 | MEN1 (0.50) | LMNAHPGDMAOBMAOAMEN1 | |
| SCHEMBL1270779 | 0.87 | HPGD (0.53) | LMNAHPGDMAOBMAOAMEN1 | |
| SCHEMBL3124651 | 0.86 | LMNA (0.55) | LMNAHPGDMAOBMEN1KMT2A | |
| SCHEMBL3124647 | 0.86 | LMNA (0.55) | LMNAHPGDMAOBMEN1KMT2A | |
| SCHEMBL29475634 | 0.83 | LMNA (0.69) | LMNAHPGDMAOBMEN1KMT2A | |
| SCHEMBL29788280 | 0.83 | LMNA (0.65) | LMNAHPGDMAOBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3705471-A1 | DOUBLE-HEADED PROTEASE INHIBITOR | UBE Industries, Ltd. (JP) | 2020-09-09 | — | — | EP | disclosed |
| CN-111542511-A | Double-headed inhibitors of proteolytic enzymes | 宇部兴产株式会社 | 2020-08-14 | — | — | CN | disclosed |
| US-8076359-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-12-13 | — | — | US | disclosed |
| EP-2097377-B1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2010-07-07 | — | — | EP | disclosed |
| US-20100063091-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2010-03-11 | — | — | US | disclosed |
| EP-2097377-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008058387-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2008-05-22 | — | — | WO | disclosed |
| WO-1997027183-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063091-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | LMNA 2244/4885HPGD 452/4885MAOB 1213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.