Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.36 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.35 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26111723 | 0.82 | SCN4A (0.47) | KEAP1KMT2ASCN4AMAPK10JMJD6 | |
| SCHEMBL25258821 | 0.78 | BRD4 (0.38) | KMT2AMAPTPIK3CAPIK3CBPIK3CG | |
| SCHEMBL31415329 | 0.77 | KEAP1 (0.55) | KEAP1KMT2AKDM4ENSD2ALDH1A1 | |
| SCHEMBL31415382 | 0.76 | KEAP1 (0.53) | KEAP1KMT2AKDM4ENSD2ALDH1A1 | |
| SCHEMBL31415385 | 0.76 | KEAP1 (0.49) | KEAP1 | |
| SCHEMBL31128114 | 0.74 | KMT2A (0.53) | KEAP1KMT2ASCN4ACASP6 | |
| SCHEMBL2277762 | 0.74 | KMT2A (0.53) | KEAP1KMT2ASCN4ACASP6 | |
| SCHEMBL31415414 | 0.73 | KEAP1 (0.50) | KEAP1KMT2AKDM4ENSD2ALDH1A1 | |
| SCHEMBL31415248 | 0.72 | KEAP1 (0.49) | KEAP1KMT2AKDM4ENSD2ALDH1A1 | |
| SCHEMBL712310 | 0.72 | TSHR (0.48) | KMT2AKDM4ENSD2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3753926-B1 | SPIRO COMPOUND AS INDOLEAMINE-2,3-DIOXYGENASE INHIBITOR | SHANGHAI INST ORGANIC CHEMISTRY CAS (CN) | 2024-10-09 | — | — | EP | disclosed |