Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | MITF | O75030 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3123717 | 0.77 | TSHR (0.47) | LMNAMEN1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL3120645 | 0.75 | DGAT2 (0.43) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL2909821 | 0.74 | LMNA (0.45) | LMNASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL3131347 | 0.72 | PDE4A (0.49) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL2907010 | 0.71 | NPC1 (0.45) | LMNAMEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL2908738 | 0.70 | RCE1 (0.42) | LMNATSHRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3612256 | 0.70 | TSHR (0.87) | LMNATSHRRAB9AL3MBTL1POLB | |
| SCHEMBL1962883 | 0.70 | TSHR (0.62) | TSHRL3MBTL1MRGPRX4POLBPPARA | |
| SCHEMBL19279467 | 0.70 | ALDH1A1 (0.50) | SMN1; SMN2NPC1RAB9AMAPTMRGPRX4 | |
| SCHEMBL2909625 | 0.69 | TP53 (0.47) | LMNAMEN1KMT2ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |