Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14574858 | 0.77 | POLB (0.35) | POLBHTT | |
| SCHEMBL842010 | 0.72 | HTT (0.50) | POLBHTT | |
| SCHEMBL11497456 | 0.68 | HTT (0.47) | POLBHTT | |
| SCHEMBL3122740 | 0.68 | POLB (0.35) | POLBHTT | |
| SCHEMBL2964693 | 0.67 | DAPK3 (0.41) | — | |
| SCHEMBL10816029 | 0.65 | ALDH1A1 (0.51) | POLBHTT | |
| SCHEMBL14574904 | 0.64 | POLB (0.32) | POLBHTT | |
| SCHEMBL31614612 | 0.62 | DHFR (0.35) | POLBHTT | |
| SCHEMBL10940831 | 0.62 | POLB (0.35) | POLBHTT | |
| SCHEMBL112571 | 0.62 | HTT (0.52) | POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2143707-A2 | Secondary diamine | Albermarle Corporation (US) | 2010-01-13 | — | — | EP | disclosed |