Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CRHBP | P24387 | 2/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10821300 | 0.89 | MAPT (0.51) | TSHRTDP1LMNAMAPTMEN1 | |
| SCHEMBL3880017 | 0.84 | CYP19A1 (0.64) | TSHRLMNAMAPTMEN1KMT2A | |
| SCHEMBL9681150 | 0.83 | LMNA (0.60) | TSHRTDP1LMNAMAPTMEN1 | |
| SCHEMBL2729695 | 0.82 | ALDH1A1 (0.63) | TSHRTDP1LMNAMAPTMEN1 | |
| SCHEMBL3128740 | 0.82 | MEN1 (0.58) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL28090620 | 0.82 | MEN1 (0.58) | LMNAMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL2002273 | 0.81 | MAPT (0.55) | TSHRTDP1LMNAMAPTMEN1 | |
| SCHEMBL28090618 | 0.81 | MAPT (0.45) | TSHRTDP1LMNAMAPTMEN1 | |
| SCHEMBL10139199 | 0.80 | LMNA (0.55) | TSHRTDP1LMNAMAPTMEN1 | |
| SCHEMBL2716434 | 0.79 | LMNA (0.70) | TDP1LMNAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |