SCHEMBL3125894

SCHEMBL3125894

COc1ccc(/C=C/C(=O)C(C)(C)C)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 1.00
KDM4E B2RXH2 2/20 0.69
ALDH1A1 P00352 2/20 0.69
SMN1; SMN2 Q16637 2/20 0.69
HPGD P15428 1/20 0.69
ALOX15 P16050 1/20 0.69
MAPK1 P28482 1/20 0.69
HSD17B10 Q99714 1/20 0.69
NFE2L2 Q16236 1/20 0.67
ABCG2 Q9UNQ0 4/20 0.65
MEN1 O00255 2/20 0.65
TNFRSF1A P19438 1/20 0.58
JUN P05412 1/20 0.57
NFKB1 P19838 1/20 0.57
PDE4A P27815 1/20 0.57
PDE4B Q07343 1/20 0.57
PDE4C Q08493 1/20 0.57
PDE4D Q08499 1/20 0.57
CA1 P00915 1/20 0.57
CA2 P00918 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3125899 1.00 KMT2A (1.00) KMT2AKDM4EALDH1A1SMN1; SMN2HPGD
SCHEMBL29497174 0.90 KMT2A (0.82) KMT2AKDM4EALDH1A1SMN1; SMN2HPGD
SCHEMBL30130359 0.90 KMT2A (0.82) KMT2AKDM4EALDH1A1SMN1; SMN2HPGD
SCHEMBL10054233 0.90 KMT2A (0.82) KMT2AKDM4EALDH1A1SMN1; SMN2HPGD
SCHEMBL30130358 0.90 KMT2A (0.82) KMT2AKDM4EALDH1A1SMN1; SMN2HPGD
SCHEMBL9907012 0.88 KMT2A (0.78) KMT2AKDM4EALDH1A1SMN1; SMN2HPGD
SCHEMBL10001150 0.88 KMT2A (0.78) KMT2AKDM4EALDH1A1HPGDALOX15
SCHEMBL16788876 0.88 KMT2A (0.78) KMT2AKDM4EALDH1A1SMN1; SMN2HPGD
SCHEMBL23023653 0.86 KMT2A (0.75) KMT2AKDM4EALDH1A1SMN1; SMN2HPGD
SCHEMBL19717945 0.86 KMT2A (0.75) KMT2AKDM4EALDH1A1SMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7166274-B2 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds L'OREAL (FR) 2007-01-23 US claimed
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SOCIETE L'OREAL S.A. (FR) 2004-03-11 US claimed
EP-1370232-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2003-12-17 EP claimed
US-6627180-B2 Particles having protection factor UV-APPD and an amino substituted 2-hydroxybenzophenone SOCIETE L'OREAL S.A. (FR) 2003-09-30 US claimed
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS SOCIETE L'OREAL S.A. (FR) 2003-08-14 US claimed
EP-1317918-A1 Cosmetic sunscreen compositions based on synergistic filter mixture and their use L'OREAL (FR) 2003-06-11 EP claimed
WO-2002056858-A1 SOLAR PROTECTION COMPOSITIONS L'OREAL (FR) 2002-07-25 WO claimed
WO-2002049597-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2002-06-27 WO claimed
EP-3709966-B1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT OREAL (FR) 2024-12-11 EP disclosed
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2021-11-11 US disclosed
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2021-11-11 US disclosed
CN-107847414-B Composition comprising a UV screening agent, an anionically crosslinked hydrophilic polymer, a surfactant having an HLB less than or equal to 5, and a siloxane copolymer 欧莱雅 2021-09-10 CN disclosed
EP-3185843-B1 GEL COMPOSITION AND GEL COMPRISING A UV FILTER OREAL (FR) 2021-08-11 EP disclosed
EP-3185843-B1 GEL COMPOSITION AND GEL COMPRISING A UV FILTER OREAL (FR) 2021-08-11 EP disclosed
EP-1317918-A1 Cosmetic sunscreen compositions based on synergistic filter mixture and their use L'OREAL (FR) 2003-06-11 EP disclosed
EP-1302197-A1 Use of amphiphilic copolymers to stabilise dispersions of non-soluble organic compounds filtering UV light L'OREAL (FR) 2003-04-16 EP disclosed
US-20030053966-A1 Insoluble organic UV screening agents of aryl vinylene ketone type, and cosmetic use thereof L'OREAL (FR) 2003-03-20 US disclosed
EP-1281391-A1 Organic insoluble UV filters of the aryl vinylene ketone type and their use in cosmetics L'OREAL (FR) 2003-02-05 EP disclosed
WO-2002056858-A1 SOLAR PROTECTION COMPOSITIONS L'OREAL (FR) 2002-07-25 WO disclosed
WO-2002049597-A2 COSMETIC SOLAR PROTECTION COMPOSITIONS BASED ON A SYNERGIC MIXTURE OF FILTERS AND USES L'OREAL (FR) 2002-06-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040047820-A1 Synergistically high SPF photoprotective UV-screening compositions comprising insoluble organic sunscreen particles/diarylbutadiene compounds SUCLG1, CUTA, DLD KMT2A 3376/4885KDM4E 1942/4885ALDH1A1 246/4885
US-20030053966-A1 Insoluble organic UV screening agents of aryl vinylene ketone type, and cosmetic use thereof PRKDC, AHR, TYR KMT2A 1006/4885KDM4E 173/4885ALDH1A1 414/4885
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 KMT2A 3476/4885KDM4E 2944/4885ALDH1A1 3802/4885
US-20030152532-A1 SYNERGISTICALLY UV-PHOTOPROTECTING COMPOSITIONS COMPRISING MIXED SCREENING AGENTS HADHB, SDHA, ERCC4 KMT2A 3626/4885KDM4E 3030/4885ALDH1A1 193/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.