SCHEMBL31269192

SCHEMBL31269192

Cc1cnc(Cn2c(-c3ccc(O[C@H]4CCN(C)C4)cc3Cl)nc3c(OC4(C)CC4)ncnc32)s1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 18/20 0.37
▸ TLR7 Q9NYK1 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31268969 0.96 PIK3CD (0.37) PIK3CDTLR7
SCHEMBL31269245 0.94 PIK3CD (0.35) PIK3CDTLR7
SCHEMBL31269315 0.90 PIK3CD (0.36) PIK3CD
SCHEMBL31269162 0.89 PIK3CD (0.35) PIK3CD
SCHEMBL31269013 0.88 PIK3CD (0.39) PIK3CD
SCHEMBL31269089 0.87 PIK3CD (0.34) PIK3CD
SCHEMBL31268923 0.87 PIK3CD (0.34) PIK3CD
SCHEMBL31269171 0.85 DRD2 (0.37) PIK3CDTLR7
SCHEMBL31269378 0.84 PIK3CD (0.34) PIK3CD
SCHEMBL31269268 0.84 CHRNB4 (0.40) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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