SCHEMBL31269337

SCHEMBL31269337

CC1(Oc2ncnc3c2nc(-c2ccc(CC(N)=O)cc2Cl)n3Cc2ccccc2C#N)CC1

nearest known ligand 0.39

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 3/20 0.39
▸ DPP4 P27487 14/20 0.35
▸ CYP3A4 P08684 4/20 0.34
▸ PIK3CD O00329 1/20 0.34
▸ DGAT1 O75907 1/20 0.33
▸ CNR2 P34972 1/20 0.32
▸ GPR119 Q8TDV5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31268995 0.91 DPP4 (0.40) DPP4PIK3CDGPR119
SCHEMBL31268830 0.91 DPP4 (0.35) CNR1DPP4PIK3CDDGAT1GPR119
SCHEMBL31268747 0.90 CNR1 (0.36) CNR1CYP3A4PIK3CDDGAT1CNR2
SCHEMBL31269049 0.89 GPR119 (0.37) CNR1PIK3CDDGAT1CNR2GPR119
SCHEMBL31269290 0.89 PIK3CD (0.37) CNR1PIK3CDDGAT1CNR2
SCHEMBL31269102 0.88 PIK3CD (0.35) CNR1PIK3CDDGAT1CNR2GPR119
SCHEMBL31268964 0.88 CNR1 (0.37) CNR1DPP4CYP3A4PIK3CDGPR119
SCHEMBL31269194 0.87 TLR7 (0.36) PIK3CDDGAT1CNR2GPR119
SCHEMBL31269283 0.87 PIK3CD (0.38) CNR1PIK3CDDGAT1CNR2
SCHEMBL31268911 0.87 GPR119 (0.36) CNR1PIK3CDDGAT1CNR2GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4689155-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024201368-A1 USE OF INHIBITORS TO INCREASE EFFICIENCY OF CRISPR/CAS INSERTIONS ASTRAZENECA AB (SE) 2024-10-03 — — WO disclosed
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