Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | CCR1 | P32246 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18282707 | 0.86 | OPRL1 (0.55) | OPRL1OPRM1OPRD1OPRK1MAOA | |
| SCHEMBL29588372 | 0.82 | SLC6A3 (0.53) | OPRL1OPRM1OPRD1OPRK1MAOA | |
| SCHEMBL24394078 | 0.82 | OPRL1 (0.53) | OPRL1OPRM1OPRD1OPRK1MAOA | |
| SCHEMBL20455678 | 0.81 | SLC6A3 (0.56) | OPRL1OPRM1OPRD1OPRK1MAOA | |
| SCHEMBL1414020 | 0.80 | OPRL1 (0.56) | OPRL1OPRM1OPRD1OPRK1KDM1A | |
| SCHEMBL3640272 | 0.79 | OPRM1 (0.46) | OPRL1OPRM1OPRD1OPRK1DRD2 | |
| SCHEMBL24397813 | 0.78 | OPRL1 (0.49) | OPRL1OPRM1OPRD1OPRK1MAOA | |
| SCHEMBL24398040 | 0.78 | P2RY14 (0.49) | OPRL1OPRM1OPRD1OPRK1MAOA | |
| SCHEMBL653874 | 0.78 | DRD2 (0.59) | OPRL1OPRM1OPRD1OPRK1MAOA | |
| Hydrochloric Acid SCHEMBL23578391 | 0.76 | DRD2 (0.58) | OPRL1OPRM1OPRD1OPRK1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |
| EP-0666854-A1 | NEUROPROTECTIVE 3,4-DIHYDRO-2(1H)-QUINOLONE COMPOUNDS. | PFIZER (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010166-A1 | NEUROPROTECTIVE 3,4-DIHYDRO-2(1H)-QUINOLONE COMPOUNDS | PFIZER INC. (US) | 1994-05-11 | — | — | WO | disclosed |