Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30063495 | 0.88 | LMNA (0.43) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL29502235 | 0.86 | LMNA (0.49) | LMNAPOLBSMN1; SMN2GPR119 | |
| SCHEMBL23859720 | 0.82 | LMNA (0.49) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL30013395 | 0.81 | LMNA (0.48) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL30376526 | 0.81 | LMNA (0.43) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL31365786 | 0.81 | LMNA (0.43) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL29655416 | 0.81 | LMNA (0.50) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL30467459 | 0.80 | LMNA (0.47) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL31532476 | 0.79 | LMNA (0.41) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 | |
| SCHEMBL18639389 | 0.79 | LMNA (0.46) | LMNAPOLBSMN1; SMN2GBA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4731309-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2026-04-29 | — | — | EP | disclosed |
| WO-2024263586-A1 | KRAS PROTEOLYSIS TARGETING CHIMERAS | PAQ Therapeutics Inc. (US) | 2024-12-26 | — | — | WO | disclosed |