Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31282074 | 0.88 | LMNA (0.44) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL23859720 | 0.81 | LMNA (0.49) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL30013395 | 0.80 | LMNA (0.48) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL30376526 | 0.80 | LMNA (0.43) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL31365786 | 0.80 | LMNA (0.43) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL30467459 | 0.79 | LMNA (0.47) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL31532476 | 0.78 | LMNA (0.41) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL18639389 | 0.78 | LMNA (0.46) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL30177247 | 0.77 | LMNA (0.44) | LMNAPOLBSMN1; SMN2GBA2HRH2 | |
| SCHEMBL22835443 | 0.76 | GPR119 (0.42) | SMN1; SMN2GPR119EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4333836-A1 | DEUTERATED IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236339-A1 | DEUTERATED IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |