SCHEMBL31290657

SCHEMBL31290657

CNC(=O)c1ccc2c(c1)sc1nc(-c3ccc(C4CCN(C(=O)OC(C)(C)C)C4)cc3F)cn12

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 9/20 0.46
▸ LMNA P02545 5/20 0.46
▸ TP53 P04637 3/20 0.46
▸ ALDH1A1 P00352 3/20 0.45
▸ KDM4E B2RXH2 2/20 0.45
▸ NPC1 O15118 1/20 0.45
▸ ATM Q13315 1/20 0.45
▸ THRB P10828 3/20 0.44
▸ HPGD P15428 2/20 0.43
▸ ALOX15 P16050 1/20 0.43
▸ HSD17B10 Q99714 1/20 0.43
▸ POLB P06746 1/20 0.42
▸ RXFP1 Q9HBX9 2/20 0.42
▸ GPR119 Q8TDV5 1/20 0.41
▸ SLC2A1 P11166 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26987414 1.00 MAPT (0.46) MAPTLMNATP53ALDH1A1KDM4E
SCHEMBL30722122 1.00 MAPT (0.46) MAPTLMNATP53ALDH1A1KDM4E
SCHEMBL26987534 0.91 GPR119 (0.51) MAPTLMNATP53ALDH1A1KDM4E
SCHEMBL30722063 0.91 GPR119 (0.51) MAPTLMNATP53ALDH1A1KDM4E
SCHEMBL30722115 0.90 MAPT (0.52) MAPTLMNATP53ALDH1A1KDM4E
SCHEMBL26987410 0.90 MAPT (0.52) MAPTLMNATP53ALDH1A1KDM4E
SCHEMBL31327740 0.88 PDE4B (0.45) MAPTALDH1A1KDM4EHPGDGPR119
SCHEMBL26985173 0.88 PDE4B (0.45) MAPTALDH1A1KDM4EHPGDGPR119
SCHEMBL30727281 0.88 PDE4B (0.45) MAPTALDH1A1KDM4EHPGDGPR119
SCHEMBL31290609 0.88 MAPT (0.46) MAPTLMNATP53ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119233976-A Modulators of c-MYC mRNA translation and their use in the treatment of cancer 艾尼莫生物科技公司 2024-12-31 — — CN disclosed
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