Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134727 | 0.78 | DRD2 (0.36) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL3124211 | 0.77 | OPRM1 (0.34) | ALDH1A1KDM4ETDP1KMT2A | |
| SCHEMBL15273946 | 0.70 | OPRM1 (0.38) | ALDH1A1KDM4EHTTKMT2AHTR1A | |
| SCHEMBL4945693 | 0.69 | ALDH1A1 (0.40) | ALDH1A1KDM4EHTTHPGDTDP1 | |
| SCHEMBL4946970 | 0.69 | ALDH1A1 (0.42) | ALDH1A1KDM4EHTTHPGDTDP1 | |
| Hydrochloric Acid SCHEMBL6416217 | 0.68 | ALDH1A1 (0.41) | ALDH1A1KDM4EHTTHPGDTDP1 | |
| Bromide SCHEMBL6417388 | 0.68 | ALDH1A1 (0.41) | ALDH1A1KDM4EHTTHPGDTDP1 | |
| SCHEMBL369052 | 0.68 | HRH3 (0.36) | ALDH1A1KDM4ETDP1HTR1A | |
| SCHEMBL13728950 | 0.67 | LMNA (0.36) | ALDH1A1KDM4EHTTHPGDKMT2A | |
| SCHEMBL15273947 | 0.63 | CYP2A13 (0.38) | ALDH1A1KDM4EHPGDKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216791-A1 | PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA (SE) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216791-A1 | PYRIDINYLQUINAZOLINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | BRAF, RAF1, ARAF | ALDH1A1 948/4885KDM4E 2452/4885HTT 4823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.