SCHEMBL31294591

SCHEMBL31294591

N#Cc1cc(OCC(F)(F)F)cc(C(F)F)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 4/20 0.46
▸ ALDH1A1 P00352 2/20 0.46
▸ EPAS1 Q99814 2/20 0.35
▸ CYP17A1 P05093 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ CYP2C19 P33261 1/20 0.35
▸ MEN1 O00255 4/20 0.35
▸ KMT2A Q03164 4/20 0.35
▸ LMNA P02545 3/20 0.35
▸ HTT P42858 2/20 0.35
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ NPSR1 Q6W5P4 2/20 0.35
▸ PAX8 Q06710 2/20 0.35
▸ S1PR2 O95136 1/20 0.35
▸ S1PR4 O95977 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ XBP1 P17861 1/20 0.35
▸ S1PR3 Q99500 1/20 0.35
▸ S1PR5 Q9H228 1/20 0.35
▸ AR P10275 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31294690 0.79 MAPT (0.50) MAPTALDH1A1EPAS1MEN1KMT2A
SCHEMBL31294594 0.79 MAPT (0.50) MAPTALDH1A1MEN1KMT2ALMNA
SCHEMBL31294731 0.78 MAPT (0.49) MAPTALDH1A1EPAS1CYP2C9MEN1
SCHEMBL2279165 0.78 MAPT (0.49) MAPTALDH1A1EPAS1CYP17A1CYP2C9
SCHEMBL3628529 0.75 EPAS1 (0.41) ALDH1A1EPAS1AR
SCHEMBL2566899 0.74 MRGPRX4 (0.50) MAPTALDH1A1MEN1KMT2ALMNA
SCHEMBL21268248 0.73 MAPT (0.43) MAPTALDH1A1CYP17A1CYP2C9CYP2C19
SCHEMBL1890750 0.73 VCAM1 (0.38) EPAS1MEN1KMT2A
SCHEMBL31294818 0.73 ALDH1A1 (0.44) MAPTALDH1A1MEN1KMT2ALMNA
SCHEMBL28301421 0.72 TBXAS1 (0.46) MAPTALDH1A1EPAS1SMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735423-A1 KV7 MODULATORS Saniona A/S (DK) 2026-05-06 — — EP disclosed
WO-2025003343-A1 KV7 MODULATORS SANIONA A/S (DK) 2025-01-02 — — WO disclosed
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