Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20073447 | 0.89 | PARP1 (0.37) | — | |
| SCHEMBL15647885 | 0.82 | LMNA (0.39) | NOTUMACHE | |
| SCHEMBL23566378 | 0.78 | NOS3 (0.52) | NOS3NOS1NOS2NOTUMACHE | |
| SCHEMBL19153853 | 0.78 | NOS3 (0.35) | NOS3NOS1NOS2SIGMAR1CTNNB1 | |
| SCHEMBL18238924 | 0.74 | NOS3 (0.33) | NOS3NOS1NOS2 | |
| SCHEMBL2110414 | 0.74 | HTR2A (0.39) | — | |
| SCHEMBL14070900 | 0.73 | PNMT (0.41) | NOTUM | |
| SCHEMBL24317739 | 0.71 | CA1 (0.33) | — | |
| SCHEMBL18168290 | 0.70 | EGFR (0.38) | — | |
| SCHEMBL17224575 | 0.70 | ACHE (0.38) | NOS3NOS1NOS2ACHECTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024217348-A1 | KIF18A INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 南京同诺康医药科技有限公司 | 2024-10-24 | — | — | WO | disclosed |