Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3116158 | 0.82 | ALDH1A1 (0.44) | GPR35HPGDALDH1A1HSD17B10CISD2 | |
| SCHEMBL3228565 | 0.77 | POLB (0.47) | GPR35HPGDALDH1A1TP53LMNA | |
| SCHEMBL6803577 | 0.77 | GPR35 (0.47) | GPR35HPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL3066973 | 0.76 | ALDH1A1 (0.62) | HPGDALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6808074 | 0.72 | GPR35 (0.42) | GPR35HPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL8290785 | 0.72 | ALDH1A1 (0.58) | HPGDALDH1A1HSD17B10TP53LMNA | |
| SCHEMBL1498222 | 0.70 | GSK3B (0.44) | GPR35ALDH1A1CYP1A2PTPN1 | |
| SCHEMBL5727379 | 0.68 | GPR35 (0.42) | GPR35ALDH1A1LMNAPOLBRECQL | |
| SCHEMBL4753776 | 0.68 | GPR35 (0.68) | GPR35HPGDALDH1A1LMNANPSR1 | |
| SCHEMBL319190 | 0.68 | GPR35 (0.57) | GPR35HPGDALDH1A1NPSR1PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001126-A1 | THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-01-07 | — | — | WO | disclosed |