Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.66 |
| ▸ | MAOB | P27338 | 3/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134040 | 0.84 | MAPT (0.64) | MAPTMAOBTHRBALDH1A1KDM4E | |
| SCHEMBL3130403 | 0.82 | KDM4E (0.73) | MAPTMAOBTHRBALDH1A1KDM4E | |
| SCHEMBL5274399 | 0.79 | ALDH1A1 (0.61) | MAPTMAOBTHRBALDH1A1KDM4E | |
| SCHEMBL3124699 | 0.79 | ALDH1A1 (0.77) | MAPTMAOBTHRBALDH1A1KDM4E | |
| SCHEMBL3134218 | 0.79 | ALDH1A1 (0.68) | MAPTMAOBTHRBALDH1A1KDM4E | |
| SCHEMBL13757050 | 0.79 | ALDH1A1 (0.68) | MAPTMAOBTHRBALDH1A1KDM4E | |
| SCHEMBL3135512 | 0.78 | IMPDH2 (0.60) | MAPTMAOBTHRBALDH1A1KDM4E | |
| SCHEMBL17318552 | 0.78 | MAPT (0.73) | MAPTMAOBTHRBALDH1A1KDM4E | |
| SCHEMBL3133866 | 0.78 | ALDH1A1 (0.67) | MAPTMAOBTHRBALDH1A1KDM4E | |
| SCHEMBL6686813 | 0.76 | MIF (0.72) | MAPTMAOBALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021333-B1 | ANTI-PROLIFERATIVE COMPOUNDS DERIVING FROM A 3-ARYL-COUMARINE OR 3-ARYL-QUINOLIN-2-ONE AND USES THEREOF | EOS ETHICAL ONCOLOGY SCIENCE S (IT) | 2010-07-14 | — | — | EP | claimed |