Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.38 |
| ▸ | PDE4A | P27815 | 8/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126353 | 0.88 | ATM (0.54) | ATMPDE4BPDE4AKCNH2GAA | |
| SCHEMBL3132080 | 0.87 | ATM (0.42) | ATMPDE4AF7KCNH2GAA | |
| SCHEMBL3131812 | 0.85 | ATM (0.54) | ATMPDE4BPDE4AKCNH2GAA | |
| SCHEMBL3120558 | 0.84 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL3200134 | 0.83 | SLC6A2 (0.43) | PDE4BPDE4APDE4CPDE4DLMNA | |
| SCHEMBL3129614 | 0.81 | PDE4B (0.40) | PDE4BPDE4AKCNH2PDE4CPDE4D | |
| SCHEMBL3130706 | 0.79 | AAK1 (0.39) | PDE4BPDE4AKCNH2PDE4CPDE4D | |
| SCHEMBL3201429 | 0.75 | PDE4B (0.38) | PDE4BPDE4AF7KCNH2PDE4C | |
| SCHEMBL3129659 | 0.73 | PDE4B (0.38) | PDE4BPDE4AF7KCNH2PDE4C | |
| SCHEMBL16951534 | 0.71 | RAB9A (0.40) | PDE4BPDE4AKCNH2PDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010003084-A2 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |