Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26646247 | 1.00 | MAPT (0.50) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL22121152 | 0.82 | MAPT (0.50) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL27038634 | 0.79 | MAPT (0.50) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL25027163 | 0.79 | MAPT (0.53) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL26618087 | 0.76 | KIF18A (0.47) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL30642990 | 0.76 | KIF18A (0.47) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL26151092 | 0.74 | LMNA (0.47) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL26646327 | 0.73 | GAA (0.42) | MAPTALDH1A1L3MBTL1LMNAPOLB | |
| SCHEMBL23043706 | 0.73 | HTR1A (0.60) | MAPTALDH1A1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL26646367 | 0.73 | FFAR4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025036479-A1 | KINESIN KIF18A INHIBITOR AND USE THEREOF | 上海湃隆生物科技有限公司 | 2025-02-20 | — | — | WO | disclosed |
| CN-119156382-A | Kinesin KIF18A inhibitor and application thereof | 上海湃隆生物科技有限公司 | 2024-12-17 | — | — | CN | disclosed |