Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TPMT | P51580 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788761 | 1.00 | LMNA (0.53) | LMNAMAPK1HTTRAB9ATPMT | |
| SCHEMBL27909656 | 0.84 | CES2 (0.46) | LMNAMAPK1HTTRAB9ATSHR | |
| SCHEMBL7756184 | 0.83 | TPMT (0.52) | LMNAMAPK1HTTRAB9ATPMT | |
| SCHEMBL789006 | 0.81 | CES2 (0.43) | LMNAMAPK1HTTRAB9ATSHR | |
| SCHEMBL15539961 | 0.81 | PARP1 (0.53) | TSHRPOLBMAPTL3MBTL1CES2 | |
| SCHEMBL29364242 | 0.79 | TPMT (0.58) | MAPK1TPMTTSHRTP53KDM4E | |
| SCHEMBL2723610 | 0.79 | TPMT (0.58) | MAPK1TPMTTSHRTP53KDM4E | |
| SCHEMBL29349680 | 0.79 | CES2 (0.70) | LMNAMAPK1HTTRAB9ATSHR | |
| SCHEMBL27151 | 0.79 | CES2 (0.70) | LMNAMAPK1HTTRAB9ATSHR | |
| Hydrochloric Acid SCHEMBL10557218 | 0.77 | CES2 (0.67) | LMNAMAPK1HTTRAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743453-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025015178-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-16 | — | — | WO | disclosed |