SCHEMBL31324992

SCHEMBL31324992

Nc1nc2cc(-c3cccc(C(=O)NCc4ccc(F)cc4)c3)ccc2s1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.57
CYP2C19 P33261 2/20 0.57
CYP2D6 P10635 2/20 0.56
PTGER4 P35408 1/20 0.52
HDAC6 Q9UBN7 2/20 0.50
HDAC3 O15379 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
AURKA O14965 1/20 0.49
SMN1; SMN2 Q16637 2/20 0.48
RAB9A P51151 1/20 0.48
EPHX2 P34913 1/20 0.48
NR1H4 Q96RI1 1/20 0.48
MAOB P27338 1/20 0.47
CYP3A4 P08684 1/20 0.47
CFD P00746 1/20 0.47
PTGES O14684 1/20 0.47
KLKB1 P03952 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31324979 0.90 CYP2C9 (0.57) CYP2C9CYP2C19CYP2D6HDAC1SMN1; SMN2
SCHEMBL31324989 0.87 RAB9A (0.60) CYP2C9CYP2C19CYP2D6HDAC6HDAC1
SCHEMBL31325002 0.79 LIPC (0.53) CYP2C9CYP2C19CYP2D6SMN1; SMN2RAB9A
SCHEMBL31324982 0.79 MEN1 (0.54) CYP2C9CYP2C19CYP2D6CYP3A4
SCHEMBL31324993 0.78 SMN1; SMN2 (0.49) CYP2C9CYP2C19CYP2D6HDAC6SMN1; SMN2
SCHEMBL31324974 0.76 PIK3CA (0.55) PTGES
SCHEMBL31324975 0.76 PIK3CA (0.55) PTGES
SCHEMBL31324976 0.76 PIK3CA (0.55) PTGES
SCHEMBL185381 0.74 L3MBTL1 (0.64) CYP2C19HDAC6HDAC2HDAC8EPHX2
SCHEMBL31324990 0.73 RAB9A (0.47) HDAC1SMN1; SMN2RAB9AEPHX2NR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119504643-A 3- (2-Aminobenzo [ d ] thiazol-5-yl) benzamide derivative and preparation method and application thereof 贵州省天然产物研究中心 2025-02-25 CN disclosed