SCHEMBL31325545

SCHEMBL31325545

COCCCNC(=O)c1ccc(Cn2c(NC3CCCCC3)nc3ccccc32)cc1

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 3/20 0.56
ALDH1A1 P00352 3/20 0.52
POLB P06746 2/20 0.52
LMNA P02545 3/20 0.51
GAA P10253 1/20 0.51
SSTR5 P35346 2/20 0.49
HTT P42858 1/20 0.49
HPGD P15428 1/20 0.49
MAPK10 P53779 1/20 0.49
KCNH2 Q12809 3/20 0.49
NR4A2 P43354 1/20 0.48
RXFP1 Q9HBX9 1/20 0.48
HDAC1 Q13547 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
DRD2 P14416 1/20 0.47
TBXA2R P21731 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31325536 0.83 KCNH2 (0.58) NLRP3ALDH1A1POLBLMNAHTT
SCHEMBL31325539 0.82 NLRP3 (0.81) NLRP3HDAC1HDAC6DRD2TBXA2R
SCHEMBL31325528 0.81 NLRP3 (0.81) NLRP3HDAC1HDAC6DRD2TBXA2R
SCHEMBL31325524 0.80 DRD2 (0.61) NLRP3ALDH1A1POLBLMNAGAA
SCHEMBL31325564 0.80 ALDH1A1 (0.63) NLRP3ALDH1A1POLBLMNAHTT
SCHEMBL11485440 0.77 SSTR5 (0.70) ALDH1A1LMNAGAASSTR5HTT
SCHEMBL31325537 0.76 POLB (0.51) NLRP3ALDH1A1POLBLMNAGAA
SCHEMBL31325566 0.76 HDAC3 (0.71) NLRP3RXFP1HDAC1HDAC6DRD2
SCHEMBL26350295 0.76 KCNH2 (0.79) ALDH1A1LMNAGAASSTR5HTT
SCHEMBL31325506 0.74 NLRP3 (0.68) NLRP3ALDH1A1POLBHDAC1HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119060050-A Benzimidazole compound and application thereof 中国药科大学 2024-12-03 CN disclosed