SCHEMBL31326352

SCHEMBL31326352

COc1cccc(CNCCc2c[nH]c3ncc(C#N)cc23)c1

nearest known ligand 0.60

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.60
▸ HTR2A P28223 9/20 0.51
▸ FGFR1 P11362 1/20 0.47
▸ FGFR4 P22455 1/20 0.47
▸ CHEK1 O14757 2/20 0.47
▸ HTR2C P28335 1/20 0.47
▸ BCHE P06276 2/20 0.47
▸ MEN1 O00255 2/20 0.46
▸ USP2 O75604 2/20 0.46
▸ CYP1A2 P05177 2/20 0.46
▸ CYP3A4 P08684 2/20 0.46
▸ CYP2D6 P10635 2/20 0.46
▸ CYP2C19 P33261 2/20 0.46
▸ CLK4 Q9HAZ1 2/20 0.46
▸ CYP2C9 P11712 1/20 0.46
▸ MAPK1 P28482 1/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ EGLN2 Q96KS0 1/20 0.45
▸ CHRM2 P08172 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL31635980 0.92 KMT2A (0.52) KMT2AHTR2AFGFR1FGFR4CHEK1
SCHEMBL31326317 0.85 KMT2A (0.64) KMT2AHTR2AFGFR1FGFR4HTR2C
SCHEMBL31326334 0.85 HTR6 (0.49) KMT2AHTR2ACHEK1HTR2CCYP3A4
SCHEMBL31326350 0.85 KMT2A (0.64) KMT2AHTR2AFGFR1FGFR4HTR2C
SCHEMBL31326330 0.82 HTR2A (0.54) KMT2AHTR2ACHEK1HTR2CUSP2
Maleic Acid SCHEMBL31683938 0.78 BCHE (0.56) KMT2AHTR2AFGFR1FGFR4HTR2C
Fumaric Acid SCHEMBL31635942 0.78 KMT2A (0.55) KMT2AHTR2AFGFR1FGFR4HTR2C
Fumaric Acid SCHEMBL31635950 0.78 HTR6 (0.56) HTR2ACHEK1HTR2CBCHECYP3A4
SCHEMBL31326337 0.76 HTR2A (0.47) KMT2AHTR2ACHEK1CYP1A2CYP3A4
SCHEMBL25169575 0.76 KMT2A (1.00) KMT2AHTR2AMEN1MAPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735441-A1 PYRROLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF MENTAL ILLNESSES Psylo Pty Ltd (AU) 2026-05-06 — — EP disclosed
US-20250361233-A1 Compounds For Activating Serotonin Receptor Psylo Pty Ltd (AU) 2025-11-27 — — US disclosed
US-12415804-B2 Compounds for activating a serotonin receptor Psylo Pty Ltd (AU) 2025-09-16 — — US disclosed
US-20250206739-A1 Compounds Psylo Pty Ltd (AU) 2025-06-26 — — US disclosed
WO-2025000051-A1 PYRROLOPYRIDINE COMPOUNDS FOR THE TREATMENT OF MENTAL ILLNESSES Psylo Pty Ltd (AU) 2025-01-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250206739-A1 Compounds NLN, SLC18A2, PYGB KMT2A 2336/4885HTR2A 94/4885FGFR1 4151/4885
US-12415804-B2 Compounds for activating a serotonin receptor HTR2C, HTR6, HTR2A KMT2A 3246/4885HTR2A 3/4885FGFR1 3471/4885
US-20250361233-A1 Compounds For Activating Serotonin Receptor HTR2C, HTR2A, HTR6 KMT2A 3086/4885HTR2A 2/4885FGFR1 3486/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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