Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.39 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 4/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | SNCA | P37840 | 4/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | MPO | P05164 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31326334 | 0.92 | HTR6 (0.49) | HTR6SNCACHEK1CYP2C9MPO | |
| Fumaric Acid SCHEMBL31635980 | 0.87 | KMT2A (0.52) | HTR6BCHEACHECHEK1CYP2C9 | |
| Fumaric Acid SCHEMBL31635996 | 0.86 | HTR6 (0.59) | HTR6BCHEACHESNCACHEK1 | |
| Fumaric Acid SCHEMBL31635984 | 0.86 | CHEK1 (0.44) | HTR6CHEK1CYP2C9MPOHDAC1 | |
| Fumaric Acid SCHEMBL31636020 | 0.80 | HTR2A (0.47) | HTR6CHEK1MPOCYP3A4HTR2A | |
| SCHEMBL31326314 | 0.80 | HTR6 (0.55) | HTR6BCHEACHESNCAMPO | |
| Maleic Acid SCHEMBL31683938 | 0.79 | BCHE (0.56) | HTR6BCHEACHEHDAC1HDAC3 | |
| SCHEMBL31326352 | 0.78 | KMT2A (0.60) | BCHECHEK1CYP2C9CYP3A4HTR2A | |
| SCHEMBL31326342 | 0.77 | HTR6 (0.52) | HTR6BCHEACHESNCAMPO | |
| SCHEMBL31326337 | 0.76 | HTR2A (0.47) | HTR6CHEK1CYP2C9MPOHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | Psylo Pty Ltd (AU) | 2025-11-27 | — | — | US | disclosed |
| US-12415804-B2 | Compounds for activating a serotonin receptor | Psylo Pty Ltd (AU) | 2025-09-16 | — | — | US | disclosed |
| US-20250206739-A1 | Compounds | Psylo Pty Ltd (AU) | 2025-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206739-A1 | Compounds | NLN, SLC18A2, PYGB | DRD2 226/4885HTR2A 94/4885HTR2C 23/4885 |
| US-12415804-B2 | Compounds for activating a serotonin receptor | HTR2C, HTR6, HTR2A | DRD2 96/4885HTR2A 3/4885HTR2C 1/4885 |
| US-20250361233-A1 | Compounds For Activating Serotonin Receptor | HTR2C, HTR2A, HTR6 | DRD2 71/4885HTR2A 2/4885HTR2C 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.