SCHEMBL3133031

SCHEMBL3133031

COc1cc2c(cc1N)N(CCCN(C)C)CC2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.43
HCN4 Q9Y3Q4 2/20 0.43
SLC6A4 P31645 3/20 0.42
CHRM2 P08172 2/20 0.42
HTR1A P08908 2/20 0.42
DRD3 P35462 2/20 0.42
KCNH2 Q12809 2/20 0.42
CYP3A4 P08684 1/20 0.42
ALOX15 P16050 1/20 0.42
ALDH1A1 P00352 2/20 0.42
LMNA P02545 2/20 0.42
KDM4E B2RXH2 1/20 0.42
PTK2B Q14289 1/20 0.42
ESR2 Q92731 1/20 0.42
NOS3 P29474 1/20 0.37
NOS1 P29475 1/20 0.37
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
IGF1R P08069 1/20 0.36
MAPK8 P45983 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2203691 0.92 MAPT (0.50) MAPTHCN4SLC6A4CHRM2HTR1A
SCHEMBL2061913 0.82 HCN4 (0.61) MAPTHCN4SLC6A4CHRM2HTR1A
SCHEMBL2207819 0.79 ABCB1 (0.59) MAPTKDM4EABCB1
SCHEMBL2206199 0.76 DRD2 (0.39) MAPTALDH1A1KDM4EDRD2
SCHEMBL4411978 0.76 MAPT (0.52) MAPTSLC6A4CHRM2HTR1ADRD3
SCHEMBL3344732 0.75 PDE4D (0.41) MAPTSLC6A4MAOAMAOB
SCHEMBL12319782 0.74 HCN4 (0.71) MAPTHCN4SLC6A4CHRM2HTR1A
SCHEMBL14685025 0.74 HCN4 (0.53) MAPTHCN4SLC6A4CHRM2HTR1A
SCHEMBL12428910 0.74 MEN1 (0.49) MAPTSLC6A4CYP3A4ALDH1A1LMNA
SCHEMBL2205627 0.74 IGF1R (0.46) MAPTHTR1ALMNAIGF1RMAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010045451-A1 PYRROLOPYRIMIDINE COMPOUNDS GLAXOSMITHKLINE LLC (US) 2010-04-22 WO disclosed
WO-2010045451-A1 PYRROLOPYRIMIDINE COMPOUNDS GLAXOSMITHKLINE LLC (US) 2010-04-22 WO disclosed