Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | S100B | P04271 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2203691 | 0.77 | MAPT (0.50) | MAOBMAOASLC6A4GAASMN1; SMN2 | |
| SCHEMBL27580531 | 0.77 | POLB (0.37) | MAOBCA7MAOASLC6A4GAA | |
| SCHEMBL2206199 | 0.76 | DRD2 (0.39) | CA7HDAC1HDAC6L3MBTL1MAPT | |
| SCHEMBL14980805 | 0.76 | ALDH1A1 (0.45) | GAASMN1; SMN2MEN1KMT2AHDAC1 | |
| SCHEMBL3133031 | 0.75 | MAPT (0.43) | MAOBMAOASLC6A4MAPT | |
| SCHEMBL21635497 | 0.74 | HDAC1 (0.46) | SMN1; SMN2HDAC1HDAC6TSHR | |
| SCHEMBL12428910 | 0.74 | MEN1 (0.49) | MAOBCA7MAOASLC6A4GAA | |
| SCHEMBL9491572 | 0.74 | MAOA (0.42) | PDE4DMAOBMAOASLC6A4GAA | |
| SCHEMBL16370572 | 0.72 | ATAD2 (0.44) | GAAMEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL12813197 | 0.72 | ATAD2 (0.40) | MEN1KMT2AL3MBTL1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |