Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31656690 | 0.79 | CFTR (0.41) | KMT2AGAASMN1; SMN2KDM4EHTT | |
| SCHEMBL25360740 | 0.79 | CFTR (0.41) | KMT2AGAASMN1; SMN2KDM4EHTT | |
| SCHEMBL30784206 | 0.77 | ALDH1A1 (0.48) | RAB9AKMT2AGAAHPGDP2RX7 | |
| SCHEMBL535620 | 0.75 | KDM4E (0.39) | GAAALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL31330687 | 0.75 | KDM4E (0.39) | GAAALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL23951011 | 0.74 | RAB9A (0.41) | RAB9AKMT2AGAAHPGDALDH1A1 | |
| SCHEMBL536169 | 0.73 | KDM4E (0.50) | GAAHPGDALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL31330675 | 0.72 | CFTR (0.40) | P2RX7SMN1; SMN2 | |
| SCHEMBL662440 | 0.72 | SMYD3 (0.51) | RAB9AKMT2AGAAHPGDSMYD3 | |
| SCHEMBL30783917 | 0.71 | KMT2A (0.50) | RAB9AKMT2AHPGDSMYD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720061-A1 | TREM2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246018-A1 | TREM2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-12-05 | — | — | WO | disclosed |