SCHEMBL31330735

SCHEMBL31330735

COCCOCc1nc(C(F)(F)F)ccc1C(=O)Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 6/20 0.38
PDE4A P27815 5/20 0.38
PDE4C Q08493 5/20 0.38
PDE4D Q08499 5/20 0.38
PDE11A Q9HCR9 1/20 0.38
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
TUBB4A P04350 1/20 0.36
TUBB P07437 1/20 0.36
TUBA3C P0DPH7 1/20 0.36
TUBA1B P68363 1/20 0.36
TUBA4A P68366 1/20 0.36
TUBB4B P68371 1/20 0.36
TUBB3 Q13509 1/20 0.36
TUBB2A Q13885 1/20 0.36
TUBB8 Q3ZCM7 1/20 0.36
TUBA3E Q6PEY2 1/20 0.36
TUBA1A Q71U36 1/20 0.36
TUBA1C Q9BQE3 1/20 0.36
TUBB6 Q9BUF5 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3276376 1.00 PDE4B (0.38) PDE4BPDE4APDE4CPDE4DPDE11A
SCHEMBL29929108 0.88 NPC1 (0.40) PDE4BPDE4APDE4CPDE4DPDE11A
SCHEMBL1201731 0.88 NPC1 (0.40) PDE4BPDE4APDE4CPDE4DPDE11A
SCHEMBL18869269 0.87 TUBB4A (0.46) PDE4BPDE4APDE4CPDE4DPDE11A
SCHEMBL18487179 0.87 NPC1 (0.37) PDE4BPDE4APDE4CPDE4DPDE11A
SCHEMBL4070144 0.84 KDM4E (0.40) NPC1RAB9ATUBB4ATUBBTUBA3C
SCHEMBL29929274 0.84 KDM4E (0.40) NPC1RAB9ATUBB4ATUBBTUBA3C
SCHEMBL3758529 0.80 HCRTR1 (0.35) PDE4BPDE4APDE4CPDE4DPDE11A
SCHEMBL275480 0.79 DRD2 (0.32) PDE4BPDE4APDE4CPDE4DPDE11A
SCHEMBL30177122 0.79 DRD2 (0.32) PDE4BPDE4APDE4CPDE4DPDE11A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743443-A1 CHEMICAL PROCESS Syngenta Crop Protection AG (CH) 2026-05-20 EP disclosed
WO-2025012283-A1 CHEMICAL PROCESS SYNGENTA CROP PROTECTION AG (CH) 2025-01-16 WO disclosed