Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.46 |
| ▸ | KDM4A | O75164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 4/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31330663 | 0.92 | KDM4C (0.51) | KDM4EKDM4CKDM4AALDH1A1SMN1; SMN2 | |
| SCHEMBL1224786 | 0.74 | TYMP (0.45) | KDM4EKDM4CKDM4AALDH1A1DHODH | |
| SCHEMBL190140 | 0.73 | JAK2 (0.57) | KDM4EKDM4CKDM4AALDH1A1SMN1; SMN2 | |
| SCHEMBL12364192 | 0.72 | L3MBTL1 (0.46) | KDM4EKDM4CALDH1A1DHODHL3MBTL1 | |
| SCHEMBL24761226 | 0.70 | CYP1A2 (0.42) | KDM4EKDM4CALDH1A1DHODHL3MBTL1 | |
| SCHEMBL13272912 | 0.70 | CYP1A2 (0.42) | KDM4EKDM4CKDM4AALDH1A1DHODH | |
| SCHEMBL16543119 | 0.70 | LIPG (0.46) | KDM4EKDM4CKDM4AALDH1A1SMN1; SMN2 | |
| SCHEMBL21886927 | 0.70 | THRB (0.60) | KDM4EKDM4CKDM4AALDH1A1DHODH | |
| SCHEMBL1917991 | 0.70 | CYP1A2 (0.42) | KDM4EKDM4CKDM4AALDH1A1DHODH | |
| SCHEMBL5209445 | 0.69 | JAK2 (0.42) | KDM4EKDM4CKDM4AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720061-A1 | TREM2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246018-A1 | TREM2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-12-05 | — | — | WO | disclosed |