Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.41 |
| ▸ | YAP1 | P46937 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29704149 | 0.86 | TNNI3K (0.47) | TNNI3KMAPTTEAD1YAP1LIPE | |
| SCHEMBL22718126 | 0.83 | TEAD1 (0.55) | TNNI3KMAPTTEAD1YAP1CYP2E1 | |
| SCHEMBL31331781 | 0.82 | LIPE (0.41) | TNNI3KMAPTLIPEKDM4EMEN1 | |
| SCHEMBL31331952 | 0.80 | TNNI3K (0.47) | TNNI3KMAPTTEAD1YAP1KDM4E | |
| SCHEMBL31331820 | 0.79 | TNNI3K (0.46) | TNNI3KMAPTTEAD1YAP1KDM4E | |
| SCHEMBL22843421 | 0.74 | TEAD1 (0.41) | MAPTTEAD1YAP1LIPECYP2E1 | |
| SCHEMBL22718107 | 0.73 | TEAD1 (0.53) | TNNI3KMAPTTEAD1YAP1KMT2A | |
| SCHEMBL29438867 | 0.73 | TEAD1 (0.53) | TNNI3KMAPTTEAD1YAP1KMT2A | |
| SCHEMBL24496353 | 0.71 | TEAD1 (0.57) | TNNI3KMAPTTEAD1YAP1 | |
| SCHEMBL22718153 | 0.70 | MMP1 (0.40) | TEAD1YAP1LIPEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114466839-B | TEAD inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2025-01-07 | — | — | CN | disclosed |