SCHEMBL31332769

SCHEMBL31332769

N#Cc1cccc([C@]2(CNC(=O)[C@H]3C[C@@H]3c3ccc(Br)cc3)CCO2)c1

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DGAT2 Q96PD7 3/20 0.41
HSD11B1 P28845 1/20 0.37
CTSL P07711 1/20 0.36
CTSB P07858 1/20 0.36
PRCP P42785 2/20 0.36
MAOA P21397 1/20 0.35
ALDH1A1 P00352 1/20 0.34
P4HB P07237 1/20 0.34
SLC6A4 P31645 1/20 0.34
HRH3 Q9Y5N1 1/20 0.34
MCHR1 Q99705 2/20 0.33
HDAC4 P56524 1/20 0.33
GPR88 Q9GZN0 1/20 0.33
FPR3 P25089 1/20 0.33
FPR2 P25090 1/20 0.33
GRIN2B Q13224 1/20 0.33
CNR1 P21554 1/20 0.33
KCNH2 Q12809 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31332651 0.92 DGAT2 (0.48) DGAT2HSD11B1CTSLCTSBMAOA
SCHEMBL31332744 0.92 DGAT2 (0.48) DGAT2HSD11B1CTSLCTSBMAOA
SCHEMBL31332702 0.91 DGAT2 (0.41) DGAT2HSD11B1CTSLCTSBPRCP
SCHEMBL31332612 0.84 DGAT2 (0.36) DGAT2HSD11B1CTSLCTSBALDH1A1
SCHEMBL31332674 0.82 DGAT2 (0.40) DGAT2HSD11B1GPR88GRIN2B
SCHEMBL31332724 0.82 HSD11B1 (0.40) HSD11B1MCHR1GRIN2BKCNH2
SCHEMBL31332694 0.81 HSD11B1 (0.39) DGAT2HSD11B1MCHR1GRIN2BKCNH2
SCHEMBL31332837 0.81 HSD11B1 (0.39) HSD11B1SLC6A4MCHR1GRIN2B
SCHEMBL31332643 0.80 HSD11B1 (0.41) HSD11B1MCHR1GRIN2BKCNH2
SCHEMBL31332726 0.79 HSD11B1 (0.38) HSD11B1SLC6A4MCHR1GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709708-A1 NOVEL CARBOXAMIDE DERIVATIVES ANGELINI PHARMA S.P.A. (IT) 2026-03-18 EP disclosed
WO-2024233603-A1 NOVEL CARBOXAMIDE DERIVATIVES ICAGEN, LLC (US) 2024-11-14 WO disclosed