SCHEMBL31333243

SCHEMBL31333243

O=C(O)[C@H]1CC[C@H](Nc2ncc(F)c(-c3cccc(N4CCCCC4)c3)n2)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SYK P43405 7/20 0.46
JUN P05412 1/20 0.41
MAPK10 P53779 1/20 0.41
CDK1 P06493 2/20 0.40
CCNB1 P14635 2/20 0.40
CDK2 P24941 2/20 0.40
CCNB2 O95067 1/20 0.40
CCNE2 O96020 1/20 0.40
CCNE1 P24864 1/20 0.40
CDK5 Q00535 1/20 0.40
CDK5R1 Q15078 1/20 0.40
CCNB3 Q8WWL7 1/20 0.40
DYRK2 Q92630 2/20 0.40
MAPK1 P28482 1/20 0.40
ABL1 P00519 1/20 0.40
FLT3 P36888 1/20 0.40
TYRO3 Q06418 1/20 0.40
MERTK Q12866 1/20 0.40
GAS6 Q14393 1/20 0.40
ADORA1 P30542 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334207 0.92 ADORA1 (0.45) SYKJUNMAPK10CDK1CCNB1
SCHEMBL31334756 0.92 SYK (0.47) SYKJUNMAPK10CDK1CCNB1
SCHEMBL31334964 0.92 SYK (0.47) SYKJUNMAPK10CDK1CCNB1
SCHEMBL31334566 0.91 PIK3CA (0.47) SYKCDK1CCNB1CDK2CCNE1
SCHEMBL31333870 0.91 PIK3CA (0.47) SYKCDK1CCNB1CDK2CCNE1
SCHEMBL31333524 0.90 SYK (0.42) SYKJUNMAPK10CDK1CCNB1
SCHEMBL31333857 0.90 SYK (0.43) SYKCDK1CCNB1CDK2CCNB2
SCHEMBL31334031 0.89 MAPK8 (0.49) SYKJUNMAPK10CDK1CCNB1
SCHEMBL31334631 0.88 SYK (0.43) SYKJUNMAPK10CDK1CCNB1
SCHEMBL31333646 0.87 CDK9 (0.46) SYKMAPK10CDK1CCNB1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed