SCHEMBL31334037

SCHEMBL31334037

O=C(CBr)N1CCC(Nc2ncc(F)c(-c3cccc(N4CCOC4=O)c3)n2)CC1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 15/20 0.45
CDK2 P24941 2/20 0.40
CCNA2 P20248 1/20 0.40
MAPK3 P27361 1/20 0.40
MAPK11 Q15759 1/20 0.39
MAPK15 Q8TD08 1/20 0.39
CDK4 P11802 3/20 0.38
CDK6 Q00534 3/20 0.38
CSF1R P07333 2/20 0.38
PIK3CD O00329 1/20 0.38
CCNB2 O95067 1/20 0.38
CCNE2 O96020 1/20 0.38
CDK1 P06493 1/20 0.38
CCNB1 P14635 1/20 0.38
CCNE1 P24864 1/20 0.38
CDK5 Q00535 1/20 0.38
CDK5R1 Q15078 1/20 0.38
CCNB3 Q8WWL7 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31333762 0.95 MAPK1 (0.44) MAPK1CDK2CCNA2MAPK3MAPK11
SCHEMBL31334958 0.90 MAPK1 (0.45) MAPK1CDK2CCNA2MAPK3CDK4
SCHEMBL31333419 0.89 MAPK1 (0.42) MAPK1CDK2CCNA2MAPK3
SCHEMBL31333839 0.85 MAPK1 (0.42) MAPK1CDK2CCNA2MAPK3CDK4
SCHEMBL31334703 0.85 MAPK1 (0.42) MAPK1CDK2CCNA2MAPK3CDK4
SCHEMBL31334173 0.85 MAPK1 (0.42) MAPK1CDK2CCNA2MAPK3CDK4
SCHEMBL31334329 0.84 CDK9 (0.42) MAPK1CDK2CCNA2MAPK3CDK4
SCHEMBL31334455 0.84 CDK9 (0.42) MAPK1CDK2CCNA2MAPK3CDK4
SCHEMBL31334897 0.84 CDK6 (0.42) MAPK1CDK2CCNA2MAPK3CDK4
SCHEMBL31334547 0.84 MAPK1 (0.48) MAPK1CDK2CCNA2MAPK3MAPK11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed