SCHEMBL31334086

SCHEMBL31334086

CC(C)(C)OC(=O)N[C@H]1CC[C@H](Nc2ncc(F)c(-c3ccnc(C(C)(C)O)c3)n2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 5/20 0.47
CKS1B P61024 1/20 0.41
SKP1 P63208 1/20 0.41
SKP2 Q13309 1/20 0.41
MCHR1 Q99705 3/20 0.40
DYRK2 Q92630 5/20 0.39
CDK4 P11802 2/20 0.38
CCND1 P24385 2/20 0.38
CCND3 P30281 2/20 0.38
CDK6 Q00534 2/20 0.38
JAK2 O60674 1/20 0.38
JAK1 P23458 1/20 0.38
CCNB2 O95067 1/20 0.37
CCNE2 O96020 1/20 0.37
CDK1 P06493 1/20 0.37
CCNB1 P14635 1/20 0.37
CCNE1 P24864 1/20 0.37
CDK2 P24941 1/20 0.37
CDK5 Q00535 1/20 0.37
CDK5R1 Q15078 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334985 0.89 MAPK8 (0.44) MAPK1MCHR1CDK4CCND1CCND3
SCHEMBL31333890 0.85 MAPK1 (0.43) MAPK1MCHR1DYRK2CDK4CCND1
SCHEMBL31333526 0.85 MAPK1 (0.43) MAPK1MCHR1DYRK2CDK4CCND1
SCHEMBL31334321 0.85 MAPK1 (0.42) MAPK1MCHR1DYRK2CDK4CCND1
SCHEMBL31333206 0.84 CKS1B (0.51) MAPK1CKS1BSKP1SKP2MCHR1
SCHEMBL31333665 0.84 MAPK1 (0.42) MAPK1MCHR1CDK4CCND1CCND3
SCHEMBL31333476 0.84 CDK9 (0.46) MAPK1CDK4CCND1CCND3CDK6
SCHEMBL31333247 0.84 MAPK1 (0.44) MAPK1CKS1BSKP1SKP2MCHR1
SCHEMBL31333445 0.82 MAPK1 (0.47) MAPK1CKS1BSKP1SKP2MCHR1
SCHEMBL31335006 0.82 CDK2 (0.45) MAPK1DYRK2CDK4CCND1CCND3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed