SCHEMBL31334819

SCHEMBL31334819

CNC(=O)C1CC(Nc2ncc(Cl)c(-c3cccc(-n4ccccc4=O)c3)n2)C1

nearest known ligand 0.42

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SYK P43405 1/20 0.42
MAPK1 P28482 17/20 0.42
PCSK9 Q8NBP7 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31334050 0.93 MAPK1 (0.44) SYKMAPK1PCSK9
SCHEMBL31334939 0.93 MAPK1 (0.44) SYKMAPK1PCSK9
SCHEMBL31333360 0.84 MAPK3 (0.48) SYKMAPK1PCSK9
SCHEMBL31335065 0.84 MAPK1 (0.45) SYKMAPK1PCSK9
SCHEMBL31333721 0.84 MAPK1 (0.45) SYKMAPK1PCSK9
SCHEMBL31334882 0.84 SYK (0.43) SYKMAPK1PCSK9
SCHEMBL31333670 0.84 SYK (0.43) SYKMAPK1PCSK9
SCHEMBL31334678 0.84 SYK (0.48) SYKMAPK1PCSK9
SCHEMBL31334357 0.82 SYK (0.46) SYKMAPK1PCSK9
SCHEMBL31334573 0.82 MAPK1 (0.49) SYKMAPK1PCSK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4709720-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN Larkspur Biosciences, Inc. (US) 2026-03-18 EP disclosed
WO-2024233846-A1 INHIBITORS AND DEGRADERS OF PIP4K PROTEIN LARKSPUR BIOSCIENCES, INC. (US) 2024-11-14 WO disclosed