Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31335945 | 0.79 | ALDH1A1 (0.35) | TDP1MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9809527 | 0.79 | NPC1 (0.41) | SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL15836230 | 0.74 | TDP1 (0.41) | TDP1SMN1; SMN2NPC1THRBRAB9A | |
| SCHEMBL12888781 | 0.74 | CHRNB2 (0.48) | TDP1SMN1; SMN2NPC1THRBRAB9A | |
| SCHEMBL7776613 | 0.74 | FAAH (0.34) | KMT2AALDH1A1GAA | |
| SCHEMBL20925003 | 0.71 | HPGD (0.39) | TDP1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL584488 | 0.71 | TDP1 (0.47) | TDP1SMN1; SMN2NPC1THRBRAB9A | |
| SCHEMBL13589550 | 0.71 | TDP1 (0.47) | TDP1SMN1; SMN2NPC1THRBRAB9A | |
| SCHEMBL16453820 | 0.70 | KMT2A (0.62) | TDP1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10960820 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4720038-A1 | (HETERO)ARYL-CARBONYL-HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PMS2 FOR CANCER AND DEGENERATIVE ILLNESSES | Neophore Limited (GB) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246496-A1 | (HETERO)ARYL-CARBONYL-HETEROBICYCLIC COMPOUNDS AS INHIBITORS OF PMS2 FOR CANCER AND DEGENERATIVE ILLNESSES | Neophore Limited (GB) | 2024-12-05 | — | — | WO | disclosed |