Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.53 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3133731 | 1.00 | MEN1 (0.65) | MEN1KMT2ANR4A2AKR1C3AKR1C2 | |
| SCHEMBL3124651 | 0.90 | LMNA (0.55) | MEN1KMT2ANR4A2AKR1C3AKR1C2 | |
| SCHEMBL3124647 | 0.90 | LMNA (0.55) | MEN1KMT2ANR4A2AKR1C3AKR1C2 | |
| SCHEMBL862870 | 0.80 | MEN1 (0.93) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL1426961 | 0.80 | MEN1 (1.00) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL340452 | 0.79 | MEN1 (0.84) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL29788233 | 0.79 | MEN1 (0.84) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| Hydrochloric Acid SCHEMBL6841086 | 0.79 | MEN1 (0.96) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL3129603 | 0.77 | MEN1 (0.74) | MEN1KMT2ANR4A2NR4A1NR4A3 | |
| SCHEMBL7358147 | 0.76 | MEN1 (0.79) | MEN1KMT2ANR4A2NR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076359-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-12-13 | — | — | US | disclosed |
| EP-2097377-B1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD (CA) | 2010-07-07 | — | — | EP | disclosed |
| US-20100063091-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2010-03-11 | — | — | US | disclosed |
| EP-2097377-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008058387-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063091-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | MEN1 4335/4885KMT2A 4313/4885NR4A2 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.