SCHEMBL3133822

SCHEMBL3133822

C[C@@]1(O)[C@H](O)[C@@H](COP(=O)(O)ONCc2ccccc2)O[C@H]1c1nc2nc(N)[nH]c(=O)c2[nH]1

nearest known ligand 0.42

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PNP P00491 2/20 0.42
EIF4E P06730 3/20 0.37
P2RY2 P41231 3/20 0.36
P2RY4 P51582 3/20 0.36
HINT1 P49773 1/20 0.35
P2RY6 Q15077 2/20 0.33
FGFR1 P11362 1/20 0.33
FGFR2 P21802 1/20 0.33
FUT6 P51993 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3146413 0.83 P2RY2 (0.45) PNPP2RY2P2RY4P2RY6
SCHEMBL3138273 0.83 HPRT1 (0.39) PNPEIF4EP2RY2P2RY4
SCHEMBL3141537 0.81 P2RY2 (0.47) P2RY2P2RY4P2RY6
SCHEMBL15468709 0.67 HINT1 (0.53) HINT1FUT6
SCHEMBL15468734 0.67 HINT1 (0.53) HINT1FUT6
SCHEMBL13522448 0.67 HINT1 (0.53) HINT1FUT6
SCHEMBL15788429 0.67 HINT1 (0.53) HINT1FUT6
SCHEMBL13522424 0.67 HINT1 (0.53) HINT1FUT6
SCHEMBL18744143 0.67 HINT1 (0.53) HINT1FUT6
SCHEMBL6906442 0.66 P2RY2 (0.48) P2RY2P2RY4P2RY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2307434-B1 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS IDENIX PHARMACEUTICALS INC (US) 2014-02-12 EP disclosed
EP-2476690-A1 Compounds and pharmaceutical compositions for the treatment of viral infections IDENIX Pharmaceuticals, Inc. (US) 2012-07-18 EP disclosed
US-20100003217-A1 Compounds and Pharmaceutical Compositions for the Treatment of Viral Infections CRETTON-SCOTT ERIKA 2010-01-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100003217-A1 Compounds and Pharmaceutical Compositions for the Treatment of Viral Infections HAVCR2, PYGL, GOT1 PNP 17/4885EIF4E 1683/4885P2RY2 2250/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.