Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SREBF2 | Q12772 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31340992 | 0.86 | CDK5 (0.44) | SREBF2CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL31341012 | 0.84 | CDK5 (0.57) | SREBF2CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL3258037 | 0.84 | CDK5 (0.55) | SREBF2CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL31341023 | 0.82 | CDK5 (0.44) | SREBF2CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL21682898 | 0.82 | LMNA (0.48) | SREBF2CDK5CDK5R1KDM4E | |
| SCHEMBL31341109 | 0.81 | RAB9A (0.53) | SREBF2CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL31340960 | 0.81 | EGLN2 (0.47) | SREBF2CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL22816454 | 0.79 | ABL1 (0.58) | SREBF2RAB9AKDM4EMEN1NPC1 | |
| SCHEMBL31341075 | 0.78 | SMN1; SMN2 (0.48) | SREBF2CDK5CDK5R1CCNA2CDK2 | |
| SCHEMBL31340947 | 0.77 | HPGDS (0.47) | SREBF2CDK5CDK5R1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743081-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | Pretzel Therapeutics, Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025019407-A1 | MODULATORS OF MITOCHONDRIAL DNA REPLICATION | PRETZEL THERAPEUTICS, INC. (US) | 2025-01-23 | — | — | WO | disclosed |