SCHEMBL31345974

SCHEMBL31345974

Cc1cc(-c2noc(=O)[nH]2)nc(C2Cc3cc(C(F)(F)F)ccc3O2)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TERT O14746 1/20 0.36
RORC P51449 2/20 0.34
MDM2 Q00987 6/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
CNR1 P21554 1/20 0.33
NR1I2 O75469 1/20 0.33
BRS3 P32247 1/20 0.33
RARB P10826 1/20 0.32
DAO P14920 1/20 0.32
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31346161 0.86 RORC (0.35) RORCMDM2MEN1ALDH1A1LMNA
SCHEMBL31346157 0.86 RORC (0.35) RORCMDM2MEN1ALDH1A1LMNA
SCHEMBL31346159 0.86 RORC (0.35) RORCMDM2MEN1ALDH1A1LMNA
SCHEMBL31346082 0.83 CNR1 (0.38) TERTRORCALDH1A1CNR1RARB
SCHEMBL31346033 0.80 TERT (0.33) TERTMAP3K5
SCHEMBL31345987 0.77 TERT (0.35) TERT
SCHEMBL31346041 0.77 FFAR1 (0.38) RORCCNR1RARBBRD4
SCHEMBL31346059 0.77 FFAR1 (0.38) RORCCNR1RARBBRD4
SCHEMBL31346065 0.76 CNR1 (0.38) TERTRORCMDM2CNR1RARB
SCHEMBL31345972 0.74 CTSS (0.35) TERTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4712967-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST Enveda Therapeutics, Inc. (US) 2026-03-25 EP disclosed
WO-2024239000-A2 G-PROTEIN COUPLED RECEPTOR ANTAGONIST ENVEDA THERAPEUTICS, INC. (US) 2024-11-21 WO disclosed