Perchlorate

Perchlorate

SCHEMBL3135201

COc1ccc(-c2cccc(S)c2-c2ccc(OC)cc2)cc1.[O-][Cl+3]([O-])([O-])O

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC4 P56524 1/20 0.46
HDAC2 Q92769 1/20 0.46
HDAC8 Q9BY41 1/20 0.46
ABL1 P00519 3/20 0.44
ABCB1 P08183 3/20 0.44
BCR P11274 3/20 0.44
ENPP1 P22413 1/20 0.43
BACE1 P56817 2/20 0.40
PTPN1 P18031 1/20 0.39
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
ESR2 Q92731 1/20 0.38
TP53 P04637 1/20 0.38
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
PTGS1 P23219 1/20 0.38
PTGS2 P35354 1/20 0.38
FGFR1 P11362 1/20 0.38
SRC P12931 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6267998 0.92 ABL1 (0.50) HDAC4HDAC2HDAC8ABL1ABCB1
Bromide SCHEMBL3130114 0.90 ABL1 (0.49) HDAC4HDAC2HDAC8ABL1ABCB1
Perchlorate SCHEMBL3135944 0.82 ENPP1 (0.39) ENPP1NPC1RAB9ATP53TSHR
Trifluoromethanesulfonic Acid SCHEMBL3143639 0.80 ENPP1 (0.46) HDAC4HDAC2HDAC8ABL1ABCB1
Perchlorate SCHEMBL3126960 0.80 ABL1 (0.40) ABL1ABCB1BCRBACE1PTPN1
SCHEMBL3143806 0.80 PTGS2 (0.42) HDAC4HDAC2HDAC8NPC1RAB9A
Perchlorate SCHEMBL3132388 0.79 PTGS2 (0.38) TP53SMN1; SMN2PTGS1PTGS2FGFR1
Perchlorate SCHEMBL3140978 0.79 ENPP1 (0.40) ABL1ENPP1PTGS1PTGS2FGFR1
Perchlorate SCHEMBL3139518 0.78 GPR84 (0.36) NPC1RAB9ATP53SMN1; SMN2KMT2A
SCHEMBL3132308 0.77 HDAC4 (0.41) HDAC4HDAC2HDAC8ABL1ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7642368-B2 for use as acid generator in semiconductor manufacture; triarylsulfonium salt having a structure that only one aromatic ring of three is different, in a high yield and by-product inhibition; reacting a diaryl sulfoxide with an aryl Grignard reagent in presence of chlorotrialkylsilane and strong acid WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2010-01-05 US disclosed
US-20070083060-A1 for use as acid generator in semiconductor manufacture; triarylsulfonium salt having a structure that only one aromatic ring of three is different, in a high yield and by-product inhibition; reacting a diaryl sulfoxide with an aryl Grignard reagent in presence of chlorotrialkylsilane and strong acid FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) 2007-04-12 US disclosed
EP-1676835-A1 PROCESS FOR PRODUCING TRIARYLSULFONIUM SALT Wako Pure Chemical Industries, Ltd. (JP) 2006-07-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070083060-A1 for use as acid generator in semiconductor manufacture; triarylsulfonium salt having a structure that only one aromatic ring of three is different, in a high yield and by-product inhibition; reacting a diaryl sulfoxide with an aryl Grignard reagent in presence of chlorotrialkylsilane and strong acid ARSA, HAO2, HAO1 HDAC4 2637/4885HDAC2 1544/4885HDAC8 2339/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.