SCHEMBL313543

SCHEMBL313543

COC(=O)COC(=O)C(Cc1ccc(OC(C)=O)cc1)NC(=O)COCc1ccccc1.c1ccc2c(c1)CO2

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
MEN1 O00255 1/20 0.42
LMNA P02545 1/20 0.42
KMT2A Q03164 1/20 0.42
GPR34 Q9UPC5 4/20 0.40
MBTPS1 Q14703 1/20 0.40
PPARG P37231 1/20 0.40
YAP1 P46937 4/20 0.39
TACR1 P25103 1/20 0.39
CTSL P07711 1/20 0.37
MAPT P10636 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL313642 0.94 MEN1 (0.48) ALDH1A1MEN1LMNAKMT2AGPR34
SCHEMBL313542 0.85 MEN1 (0.49) ALDH1A1MEN1LMNAKMT2AGPR34
SCHEMBL313083 0.83 ALDH1A1 (0.48) ALDH1A1MEN1LMNAKMT2AGPR34
SCHEMBL2619550 0.82 MEN1 (0.58) ALDH1A1MEN1LMNAKMT2AGPR34
SCHEMBL313074 0.81 MDM4 (0.55) ALDH1A1MEN1LMNAKMT2AGPR34
SCHEMBL313378 0.80 TDP2 (0.43) ALDH1A1MEN1LMNAKMT2APPARG
SCHEMBL1855819 0.79 HDAC1 (0.45) YAP1
SCHEMBL1931510 0.79 ALDH1A1 (0.46) ALDH1A1MEN1KMT2AMAPTSMN1; SMN2
SCHEMBL313641 0.78 ALDH1A1 (0.57) ALDH1A1MEN1LMNAKMT2AGPR34
SCHEMBL314002 0.77 MEN1 (0.65) ALDH1A1MEN1LMNAKMT2AGPR34

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8664426-B2 Functionalized amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2014-03-04 US disclosed
US-20130317118-A1 FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2013-11-28 US disclosed
US-8519175-B2 Functionalized amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2013-08-27 US disclosed
US-20130030061-A1 FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2013-01-31 US disclosed
US-8309754-B2 Functionalized amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2012-11-13 US disclosed
US-20120094994-A1 FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2012-04-19 US disclosed
US-8093420-B2 Functionalized amino acids and absorbable polymers therefrom BEZWADA BIOMEDICAL, LLC (US) 2012-01-10 US disclosed
US-20090098180-A1 FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BEZWADA BIOMEDICAL, LLC (US) 2009-04-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090098180-A1 FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BCAT2, BCAT1, SLC7A1 ALDH1A1 1912/4885MEN1 2243/4885LMNA 3673/4885
US-20120094994-A1 FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BCAT2, BCAT1, SLC7A1 ALDH1A1 1912/4885MEN1 2243/4885LMNA 3673/4885
US-20130030061-A1 FUNCTIONALIZED AMINO ACIDS AND ABSORBABLE POLYMERS THEREFROM BCAT2, BCAT1, SLC7A1 ALDH1A1 1912/4885MEN1 2243/4885LMNA 3673/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.