Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | CHIT1 | Q13231 | 2/20 | 0.37 |
| ▸ | CHIA | Q9BZP6 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2010440 | 0.92 | PSEN1 (0.42) | PKMALDH1A1GAAHSD11B1KDM4E | |
| SCHEMBL4685105 | 0.92 | HSD11B1 (0.43) | ALDH1A1GAATP53HSD11B1 | |
| SCHEMBL2007974 | 0.92 | HSD11B1 (0.43) | ALDH1A1GAATP53HSD11B1 | |
| SCHEMBL2008890 | 0.88 | HSD11B1 (0.46) | HSD11B1 | |
| SCHEMBL2007089 | 0.87 | ALDH1A1 (0.42) | PKMALDH1A1L3MBTL1LMNAGAA | |
| SCHEMBL2010721 | 0.86 | PKM (0.51) | GBA1PKMALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2006592 | 0.86 | MEN1 (0.47) | PKMALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL2006326 | 0.86 | ALDH1A1 (0.50) | GBA1PKMALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2007289 | 0.86 | MEN1 (0.47) | PKMALDH1A1SMN1; SMN2LMNAGAA | |
| SCHEMBL3054414 | 0.85 | ALDH1A1 (0.40) | PKMALDH1A1LMNAGAAHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981504-B1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO DEGENERATIVE DISEASES | REMYND NV (BE) | 2010-07-21 | — | — | EP | claimed |