SCHEMBL31362476

SCHEMBL31362476

C#Cc1c(F)cc(F)cc1OC

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.31
NFE2L2 Q16236 1/20 0.31
LMNA P02545 1/20 0.31
MAPK1 P28482 1/20 0.31
HTT P42858 1/20 0.31
RAB9A P51151 1/20 0.31
EGFR P00533 1/20 0.30
FBP1 P09467 1/20 0.30
TUBB1 Q9H4B7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17992 0.80 TRPV4 (0.42) LMNAMAPK1
SCHEMBL18297519 0.79 L3MBTL1 (0.35) MAPK1HTTTUBB1
SCHEMBL31362459 0.79 EGFR (0.32) LMNAEGFR
SCHEMBL2336780 0.78 TRPV4 (0.33)
SCHEMBL17417563 0.72 TAAR1 (0.45) MAOB
SCHEMBL15243966 0.72 TUBB1 (0.32) TUBB1
SCHEMBL29005932 0.72 PDE2A (0.32) EGFRFBP1TUBB1
SCHEMBL15391492 0.72 NFE2L2 (0.43) NFE2L2LMNAMAPK1
SCHEMBL10086105 0.72 TUBB1 (0.42) MAOBNFE2L2LMNAMAPK1HTT
SCHEMBL4882783 0.71 LMNA (0.32) MAOBNFE2L2LMNAMAPK1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025034858-A1 FUSED PYRIDINES FOR THE TREATMENT OF CANCER AND OTHER INDICATIONS THERAS, INC. (US) 2025-02-13 WO disclosed