Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.73 |
| ▸ | SHBG | P04278 | 8/20 | 0.73 |
| ▸ | SERPINA6 | P08185 | 7/20 | 0.73 |
| ▸ | NR3C1 | P04150 | 6/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.73 |
| ▸ | BLM | P54132 | 4/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.73 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.73 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.73 |
| ▸ | PGR | P06401 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.69 |
| ▸ | HTR2B | P41595 | 1/20 | 0.69 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.63 |
| ▸ | TSHR | P16473 | 4/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18891189 | 0.86 | SHBG (0.77) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 | |
| SCHEMBL18891198 | 0.86 | SHBG (0.77) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 | |
| SCHEMBL8093443 | 0.86 | SHBG (0.77) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 | |
| SCHEMBL14150039 | 0.86 | SHBG (0.77) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 | |
| SCHEMBL8937171 | 0.85 | LMNA (0.72) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 | |
| SCHEMBL8853536 | 0.85 | LMNA (0.72) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 | |
| Hydroxyprogesterone SCHEMBL23456341 | 0.85 | LMNA (1.00) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 | |
| Hydroxyprogesterone SCHEMBL13558389 | 0.85 | LMNA (1.00) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 | |
| Hydroxyprogesterone SCHEMBL265609 | 0.85 | LMNA (1.00) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 | |
| Hydroxyprogesterone SCHEMBL18261234 | 0.85 | LMNA (1.00) | LMNASHBGSERPINA6NR3C1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9180132-B2 | Antimicrobial cationic steroids and methods of use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-11-10 | — | — | US | disclosed |
| US-9056048-B2 | Synthesis and use of cationic steroids for anti-inflammatory drug therapy | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-06-16 | — | — | US | disclosed |
| US-20130137668-A1 | Antimicrobial Cationic Steroids and Methods of Use | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-05-30 | — | — | US | disclosed |
| WO-2010062562-A1 | SYNTHESIS AND USE OF CATIONIC STEROIDS FOR ANTI-INFLAMMATORY DRUG THERAPY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-03 | — | — | WO | disclosed |
| US-20090124591-A1 | Synthesis and Use of Cationic Steroids for Anti-Inflammatory Drug Therapy | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2009-05-14 | — | — | US | disclosed |
| US-7442386-B2 | Synthesis and use of reagents for improved DNA lipofection and/or slow release prodrug and drug therapies | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-10-28 | — | — | US | disclosed |
| EP-1424998-A4 | SYNTHESIS AND USE OF REAGENTS FOR IMPROVED DNA LIPOFECTION AND/OR SLOW RELEASE PRODRUG AND DRUG THERAPIES | UNIV PENNSYLVANIA (US) | 2005-11-23 | — | — | EP | disclosed |
| US-20050069577-A1 | Synthesis and use of reagents for improved DNA lipofection and/or slow release prodrug and drug therapies | TRUSTEES OF UNIVERSITY OF PENNSYLVANIA | 2005-03-31 | — | — | US | disclosed |
| EP-1424998-A1 | SYNTHESIS AND USE OF REAGENTS FOR IMPROVED DNA LIPOFECTION AND/OR SLOW RELEASE PRODRUG AND DRUG THERAPIES | The Trustees of The University of Pennsylvania (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2003015757-A1 | SYNTHESIS AND USE OF REAGENTS FOR IMPROVED DNA LIPOFECTION AND/OR SLOW RELEASE PRODRUG AND DRUG THERAPIES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-02-27 | — | — | WO | disclosed |