SCHEMBL8093443

SCHEMBL8093443

CC(=O)[C@@]1(C)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SHBG P04278 8/20 0.77
LMNA P02545 8/20 0.77
SERPINA6 P08185 7/20 0.77
NR3C1 P04150 5/20 0.77
SMN1; SMN2 Q16637 5/20 0.77
BLM P54132 4/20 0.77
CYP2C19 P33261 3/20 0.77
MEN1 O00255 2/20 0.77
KMT2A Q03164 2/20 0.77
MAPT P10636 2/20 0.77
ADORA3 P0DMS8 1/20 0.77
MAPK3 P27361 1/20 0.77
SLC6A3 Q01959 1/20 0.77
PGR P06401 4/20 0.72
ALDH1A1 P00352 3/20 0.72
ADRA1A P35348 1/20 0.72
HTR2B P41595 1/20 0.72
CYP17A1 P05093 2/20 0.66
HSD17B10 Q99714 7/20 0.65
TSHR P16473 5/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18891198 1.00 SHBG (0.77) SHBGLMNASERPINA6NR3C1SMN1; SMN2
SCHEMBL14150039 1.00 SHBG (0.77) SHBGLMNASERPINA6NR3C1SMN1; SMN2
SCHEMBL18891189 1.00 SHBG (0.77) SHBGLMNASERPINA6NR3C1SMN1; SMN2
SCHEMBL5907026 0.90 SHBG (0.72) SHBGLMNASERPINA6NR3C1SMN1; SMN2
SCHEMBL27046839 0.89 SHBG (0.70) SHBGLMNASERPINA6NR3C1SMN1; SMN2
Hydroxyprogesterone SCHEMBL23456341 0.87 LMNA (1.00) SHBGLMNASERPINA6NR3C1SMN1; SMN2
Hydroxyprogesterone SCHEMBL18261234 0.87 LMNA (1.00) SHBGLMNASERPINA6NR3C1SMN1; SMN2
Hydroxyprogesterone SCHEMBL3931615 0.87 LMNA (1.00) SHBGLMNASERPINA6NR3C1SMN1; SMN2
Hydroxyprogesterone SCHEMBL14546356 0.87 LMNA (1.00) SHBGLMNASERPINA6NR3C1SMN1; SMN2
Hydroxyprogesterone SCHEMBL14523053 0.87 LMNA (1.00) SHBGLMNASERPINA6NR3C1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4677063-A1 METHODS FOR GENERATING ENDOMETRIUM ASSEMBLOIDS Babraham Institute (GB) 2026-01-14 EP disclosed
WO-2024184624-A1 METHODS FOR GENERATING ENDOMETRIUM ASSEMBLOIDS BABRAHAM INSTITUTE (GB) 2024-09-12 WO disclosed
US-20220153776-A1 ANTAGONISTS OF CB1 RECEPTOR INST NAT SANTE RECH MED (FR) 2022-05-19 US disclosed
EP-3170501-B1 ANTAGONISTS OF CB1 RECEPTOR INST NAT SANTE RECH MED (FR) 2020-07-08 EP disclosed
US-20190071465-A1 ANTAGONISTS OF CB1 RECEPTOR INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2019-03-07 US disclosed
US-10150793-B2 Antagonists of CB1 receptor INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2018-12-11 US disclosed
US-10040816-B2 Antagonists of CB1 receptor INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2018-08-07 US disclosed
EP-3170501-A1 ANTAGONISTS OF CB1 RECEPTOR INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2017-05-24 EP disclosed
US-20160145294-A1 Antagonists of CB1 Receptor INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2016-05-26 US disclosed
US-20160030449-A1 TRANSDERMAL CREAM THERAPEUTICSMD, INC. 2016-02-04 US disclosed
US-20160015707-A1 METHOD OF PROMOTING REMYELINATION UNIV CASE WESTERN RESERVE (US) 2016-01-21 US disclosed
EP-2709631-A1 ANTAGONISTS OF CB1 RECEPTOR INSERM - Institut National de la Santé et de la Recherche Médicale (FR) 2014-03-26 EP disclosed
WO-2012160006-A1 ANTAGONISTS OF CB1 RECEPTOR. INSERM (Institut National de la Santé et de la Recherche Médicale) (FR) 2012-11-29 WO disclosed
EP-0680970-B1 Medrogestone AMERICAN HOME PROD (US) 2000-11-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160030449-A1 TRANSDERMAL CREAM PGR, PGRMC2, CYP19A1 SHBG 6/4885LMNA 278/4885SERPINA6 271/4885
US-20160015707-A1 METHOD OF PROMOTING REMYELINATION CHAT, PMP22, MAG SHBG 4727/4885LMNA 1763/4885SERPINA6 3200/4885
US-10150793-B2 Antagonists of CB1 receptor CNR2, CNR1, GPR18 SHBG 593/4885LMNA 4593/4885SERPINA6 3094/4885
US-20190071465-A1 ANTAGONISTS OF CB1 RECEPTOR CNR2, CNR1, GPR18 SHBG 593/4885LMNA 4593/4885SERPINA6 3094/4885
US-10040816-B2 Antagonists of CB1 receptor CNR2, CNR1, GPR18 SHBG 593/4885LMNA 4593/4885SERPINA6 3094/4885
US-20160145294-A1 Antagonists of CB1 Receptor CNR2, CNR1, GPR18 SHBG 593/4885LMNA 4593/4885SERPINA6 3094/4885
US-20220153776-A1 ANTAGONISTS OF CB1 RECEPTOR CNR2, CNR1, GPR18 SHBG 593/4885LMNA 4593/4885SERPINA6 3094/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.