SCHEMBL3137403

SCHEMBL3137403

CC(C)(C)c1ccc(S(OS(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(c2ccccc2)c2ccc(C(C)(C)C)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 9/20 0.46
CA1 P00915 4/20 0.40
CA2 P00918 4/20 0.40
NR1H2 P55055 3/20 0.39
RORA P35398 1/20 0.39
NR1H3 Q13133 2/20 0.38
ALDH1A1 P00352 2/20 0.37
HSD17B3 P37058 1/20 0.37
NPC1 O15118 1/20 0.37
RECQL P46063 1/20 0.37
RAB9A P51151 1/20 0.37
NR1I2 O75469 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL384931 1.00 HSD11B1 (0.46) HSD11B1CA1CA2NR1H2RORA
SCHEMBL3135858 1.00 HSD11B1 (0.46) HSD11B1CA1CA2NR1H2RORA
SCHEMBL3135789 1.00 HSD11B1 (0.46) HSD11B1CA1CA2NR1H2RORA
SCHEMBL3139776 0.99 HSD11B1 (0.47) HSD11B1CA1CA2NR1H2RORA
SCHEMBL384050 0.99 HSD11B1 (0.47) HSD11B1CA1CA2NR1H2RORA
SCHEMBL2438821 0.95 HSD11B1 (0.47) HSD11B1CA1CA2RORANR1H3
SCHEMBL678362 0.95 CA1 (0.44) HSD11B1CA1CA2RORAALDH1A1
SCHEMBL51946 0.93 CA1 (0.43) HSD11B1CA1CA2RORAALDH1A1
SCHEMBL2435496 0.92 HSD11B1 (0.47) HSD11B1CA1CA2RORANR1H3
SCHEMBL3126293 0.89 CA1 (0.42) HSD11B1CA1CA2NR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1676835-B1 PROCESS FOR PRODUCING TRIARYLSULFONIUM SALT WAKO PURE CHEM IND LTD (JP) 2014-12-10 EP disclosed
US-7642368-B2 for use as acid generator in semiconductor manufacture; triarylsulfonium salt having a structure that only one aromatic ring of three is different, in a high yield and by-product inhibition; reacting a diaryl sulfoxide with an aryl Grignard reagent in presence of chlorotrialkylsilane and strong acid WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 2010-01-05 US disclosed
US-20070083060-A1 for use as acid generator in semiconductor manufacture; triarylsulfonium salt having a structure that only one aromatic ring of three is different, in a high yield and by-product inhibition; reacting a diaryl sulfoxide with an aryl Grignard reagent in presence of chlorotrialkylsilane and strong acid FUJIFILM WAKO PURE CHEMICAL CORPORATION (JP) 2007-04-12 US disclosed
EP-1676835-A1 PROCESS FOR PRODUCING TRIARYLSULFONIUM SALT Wako Pure Chemical Industries, Ltd. (JP) 2006-07-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070083060-A1 for use as acid generator in semiconductor manufacture; triarylsulfonium salt having a structure that only one aromatic ring of three is different, in a high yield and by-product inhibition; reacting a diaryl sulfoxide with an aryl Grignard reagent in presence of chlorotrialkylsilane and strong acid ARSA, HAO2, HAO1 HSD11B1 718/4885CA1 96/4885CA2 38/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.