SCHEMBL31379484

SCHEMBL31379484

Clc1ccc(I)c(OCc2cscn2)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.45
FNTA P49354 1/20 0.40
FNTB P49356 1/20 0.40
SLC6A3 Q01959 1/20 0.39
FLT1 P17948 1/20 0.39
EPHA2 P29317 1/20 0.39
KDR P35968 1/20 0.39
EPHB4 P54760 1/20 0.39
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2C19 P33261 1/20 0.38
S1PR4 O95977 2/20 0.37
NMT1 P30419 1/20 0.37
SLC6A4 P31645 3/20 0.36
HTR2A P28223 1/20 0.36
HTR2C P28335 1/20 0.36
HTR2B P41595 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23516857 0.79 MRGPRX4 (0.47) GRM5FNTAFNTBSLC6A3FLT1
SCHEMBL31379494 0.78 FLT1 (0.38) GRM5FNTAFNTBSLC6A3FLT1
SCHEMBL31379678 0.78 FLT1 (0.38) GRM5FNTAFNTBSLC6A3FLT1
SCHEMBL31379676 0.77 NOS3 (0.39) GRM5FNTAFNTBSLC6A3FLT1
SCHEMBL31379582 0.75 FLT1 (0.36) GRM5FNTAFNTBFLT1EPHA2
SCHEMBL22135524 0.73 ALDH1A1 (0.44) NPC1RAB9AKMT2ACYP1A2CYP2C19
SCHEMBL31379547 0.71 FLT1 (0.35) GRM5FNTAFNTBSLC6A3FLT1
SCHEMBL2194043 0.71 SYK (0.46) GRM5FLT1EPHA2KDREPHB4
SCHEMBL5548307 0.71 FLT1 (0.41) GRM5FLT1EPHA2KDREPHB4
SCHEMBL31379518 0.70 POLB (0.42) NPC1RAB9AS1PR4SLC6A4HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025036241-A1 COMPOUNDS AND METHODS FOR MODULATING RNA SPLICING RIBOPEUTIC INC. (CN) 2025-02-20 WO disclosed