Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.56 |
| ▸ | JAK3 | P52333 | 5/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.56 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31379877 | 0.86 | JAK3 (0.51) | JAK2JAK3PTK2GPR119 | |
| SCHEMBL20551736 | 0.86 | JAK2 (0.52) | JAK2JAK3PTK2GPR119HPGDS | |
| SCHEMBL31379913 | 0.85 | GPR119 (0.51) | JAK2JAK3PTK2GPR119HPGDS | |
| SCHEMBL31379936 | 0.85 | EGFR (0.44) | JAK2JAK3PTK2GPR119KDM4E | |
| SCHEMBL31379921 | 0.84 | ALDH1A1 (0.48) | JAK2JAK3PTK2KDM4EALDH1A1 | |
| SCHEMBL31379876 | 0.83 | GRM1 (0.48) | JAK2JAK3PTK2NAMPT | |
| SCHEMBL31379924 | 0.82 | JAK2 (0.46) | JAK2JAK3PTK2GPR119HPGDS | |
| SCHEMBL31379898 | 0.82 | SYK (0.44) | JAK2JAK3PTK2GPR119HPGDS | |
| SCHEMBL31379884 | 0.81 | ALDH1A1 (0.47) | JAK2JAK3PTK2KDM4EALDH1A1 | |
| SCHEMBL31379910 | 0.81 | JAK3 (0.51) | JAK2JAK3PTK2GPR119HPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025027560-A1 | NEW RHOJ/CDC42 INHIBITORS DEVELOPED FOR THE TREATMENT OF CANCER, BENIGN TUMORS, RETINAL DISORDERS, VASCULAR DISORDERS, AND CARDIOMYOPATHIES | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2025-02-06 | — | — | WO | disclosed |